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Dyskeratosis congenita (DKC) is a rare inherited disease characterized by the triad of abnormal skin pigmentation, nail dystrophy, and mucosal leukoplakia.

先天性角化不良(DKC)少见之遗传性疾病,三主要特徵皮肤色素甲生长及黏膜白斑

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Osmosis-消化

Early on, these lesions are usually pretty thin, so it's called thin leukoplakia.

在早期,这些病变往往较轻,因此可以将其称斑病。

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Osmosis-消化

At the cellular level, leukoplakia typically shows a thickened keratin layer.

从细胞学层面看,口腔黏膜斑的典型表现是增厚的角质层。

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Osmosis-消化

These leukoplakias are usually painless but can't be easily scraped away.

这些斑通常引起疼痛,但能被轻易刮去。

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Osmosis-消化

Now, the exact cause for leukoplakia is unknown, but a known risk factor is tobacco use.

现在我们还能明确口腔黏膜斑的致病因素,但有一个明确的高危因素:即烟草的使用。

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Osmosis-消化

These can either go away on their own, remain unchanged, or grow and become thicker, at which point it's called thick leukoplakia.

这类斑可能自行消失、保持原状或变厚;一旦变厚,就了厚斑病。

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Osmosis-消化

Signs of precancerous development include areas of leukoplakia, erythroplakia, erythroleukoplakia or any other abnormal appearing tissue or masses.

癌前征象包括口腔黏膜斑、红斑、红斑或出现其它正常的组织或肿块。

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Osmosis-消化

If it becomes bumpy it's called nodular leukoplakia, and if it becomes wart-like it's called verrucous leukoplakia.

如果斑表面变得凹凸平,便称之为结节状黏膜斑;如果斑的形状像疣,则称其为疣状黏膜斑。

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Osmosis-消化

Erythroplakias are more serious than leukoplakia because almost always when they are removed and examined under the microscope they will show severe dysplasia, or early cancer.

黏膜红斑要比黏膜斑严重得多,因为在显微镜下观察这些组织时,它们几乎都表现出了明显的异型增生,或癌变早期征象。

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Osmosis-消化

However, leukoplakia is considered a precancerous condition, meaning that compared to normal tissue, it's more likely to develop into a cancer in the future.

但是,口腔黏膜斑被认为是一种癌前病变,意思是相对于正常组织来说,它在未来癌症的可能性更大。

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Osmosis-消化

Proliferative verrucous leukoplakia can turn into a particular type of squamous cell cancer called verrucous carcinoma, and it's also sometimes called snuff-dipper's cancer since it is more common among users of snuff and other forms of chewing tobacco.

增生性疣状斑可一种特殊的鳞状细胞癌,即疣状癌,有时也叫“鼻烟”癌,因为这在鼻烟和其它形式的嚼烟使用者中更常见。

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