Finally, we gained four esterifiable quinolone analogues (compounds 22 to 25) by modifying the structures of compound 3, 14 and 16 on 3 position.

同利用所合的化合物3，14，16为模板，对们的3位羧基进行酯化反应合4喹诺酮酯类化合物：化合物22—25。