Some holoenzymes, such as pyruvate dehydrogenase, are highly compex, with several cofactors.

有一些高度复杂的，如丙酮酸脱氢。

When a catalytically active enzyme forms a complex with a cofactor a holoenzyme is produced.

蛋白和辅助因子两者结合成子时，形成具有活力的。