This is a risk for people taking warfarin, especially in large doses, without an overlapping rapid-onset blood thinner such as heparin or low molecular weight heparin.
The chemical parameters that we used for instance it was the molecular weight of compound, or the fact that the compound possesses or not some functional groups.
And then we were trying everything possible in a very logical way, whether it was basically blood thinners, whether it was low molecular weight heparins to prevent clotting.