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Altenusin was reported as myosin light chain kinase inhibitor and sphingomyelinase inhibitor.TAN-420E has antitumor activity.

TAN-420E曾有抗肿瘤活性,易氧化为Herbimycin A,者是很好的除草剂,并定抗菌活性。

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Crash Course 解剖生理学篇

Specifically, that club-headed myosin wants to get all up-close-and-personal with the actin.

具体来说,棒状头白想近距离接触白。

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Crash Course 解剖生理学篇

They've got their own famous coupling — a pretty pair of tiny protein strands called actin and myosin.

它们有自己著名联结——一对漂亮微小白质链,叫做白和白。

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TED演讲(视频版) 2022年4月合集

Like the actin and myosin in our muscles that enable us to move.

就像我们肉中白和白一样,它们使我们能够移

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Actin and myosin, the proteins of muscles, permit those bodies to move around.

白和白, 白质, 允许这些身体四处移

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Crash Course 解剖生理学篇

But the only myosin heads that can bind to those newly exposed sites are ones that are ready for action.

但是唯一能与这些新部位结合白头是那些准备好行

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Crash Course 解剖生理学篇

At this point, the myosin is totally stoked, because the bodyguards that have been frustrating it are in for a big, irresistible distraction.

在这一点上,白完全兴奋起来,因为一直让它沮丧保镖会有一个巨大、不可抗心。

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Crash Course 解剖生理学篇

They're divided lengthwise into segments called sarcomeres, which contain two even tinier strands of protein — two different kinds of myofilaments called actin and myosin.

它们在纵向上被成称为,其中包含两股更小白质——两种不同丝称为白和白。

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Crash Course 解剖生理学篇

A sarcomere contains both thin filaments, made up mostly of two light and twisty actin strands, and thick filaments, composed of thicker, lumpy-looking myosin strands.

节既包含细丝,主要由两条轻盈而扭曲白链组成,也包含粗丝,由更厚、看起来块状白链组成。

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Crash Course 解剖生理学篇

Then comes a brief period of contraction, when the myosin heads are binding, and pulling, and releasing, over and over, and the muscle fibers contract.

然后是短暂收缩,这时白头一遍又一遍地结合、拉和释放,肉纤维收缩。

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Crash Course 解剖生理学篇

When those channels are thrown open, the calcium stored inside rushes into the rest of the cell, and finally myosin is like, YES! Here we go!

当这些通道打开时,储存在其中钙会涌入细胞其余部,最后白就像,是!开始了!

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Crash Course 解剖生理学篇

So after all that, with the myosin primed for action and the bodyguards out of the way, the myosin finally binds to actin, and it is beautiful.

经过这一切,当白准备好行,保镖离开,白最终与白结合,这真是太美了。

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Crash Course 解剖生理学篇

That tension means myosin and the calcium pumps are burning up the muscle cells' ATP, and the finite supply of ATP is what makes it impossible to maintain vigorous muscle activity indefinitely.

这种张力意味着白和钙泵正在燃烧肉细胞三磷酸腺苷,而三磷酸腺苷有限供应使得肉活不可能无限期地保持旺盛。

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Crash Course 解剖生理学篇

But soon the fiber slides back down into the relaxation period, when the calcium gets pumped back into the sarcoplasmic reticulum, and the actin and myosin stop the binding cycle, and the muscle relaxes.

但很快,纤维滑回松弛期,此时钙被泵入浆网,白和白停止结合循环,肉放松。

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Crash Course 解剖生理学篇

If another action potential travels down before that can happen, even more calcium gets released, which ends up exposing more actin for myosin to bind to, and that means more force in that fiber.

如果另一个作电位在此之前下降,更多钙被释放出来,最终露出更多白来结合白,这意味着纤维中有更多力量。

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Crash Course 解剖生理学篇

You'd also re-learn that your skeletal muscles are constructed like a rope made of bundles of protein fibers, and that the smallest strands are your actin and myosin myofilaments.

你还会重新了解到你骨骼就像一根由成束白质纤维组成绳子,最小链是你白和丝。

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Crash Course 解剖生理学篇

That binding causes another shape change. But this time, it causes the myosin to release from the actin, in a tear-jerking scene like some microscopic re-creation of the finale from Titanic.

这种结合导致了另一种形状变化。但这一次,它导致白从白中释放出来,这是一个催人泪下场景,就像泰坦尼克号结局微观再现。

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Crash Course 解剖生理学篇

Because this is when the myosin breaks down its new molecule of ATP into ADP and a phosphate, which moves it into the armed position yet again, getting it ready for its next rendezvous.

因为这是白将其新 ATP 解成 ADP 和磷酸盐时候,这使它再次处于武装状态,为下一次会合做好准备。

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Crash Course 解剖生理学篇

When they bind, the myosin releases all that stored energy, and — in the excitement of it all — the myosin changes shape. It pulls on its precious actin strand, kind of like pulling a rope hand over fist.

当它们结合时,白释放所有储存能量,在兴奋中,白改变形状。它拉着它珍贵白链,有点像用手握住拳头拉绳子。

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Crash Course 解剖生理学篇

So the calcium latches on to the troponin and causes it to pull the other bodyguard protein — the tropomyosin — away from the sites on the actin strands that the myosin really wants to get its paws on.

所以钙锁住白,并使其将另一种保护白——原白——从白真正想要抓住白链上位置拉走。

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Crash Course 解剖生理学篇

When a myosin head does that, it moves into an extended position, kinda like a stretched spring — still holding on to the ADP and phosphate, and still storing the energy that was released when they were broken apart.

白头这样做时,它会移到伸展位置,有点像被拉伸弹簧——仍然抓住 ADP 和磷酸盐,仍然储存它们破裂时释放能量。

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