One is that repeated exposure to nicotine may cause nicotinic receptors to become less sensitive to nicotine.

一种理论，反复使用尼古丁可能导致烟碱对尼古丁敏感性下降。

Alright, so in this case, the patient's B cells inappropriately make antibodies that bind to nicotinic acetylcholine receptors on the muscle cells.

好了，在这种情况下，患者B细胞产生了错误抗，该抗和肌肉细胞中N胆碱相结合。

Another theory is that neurons may remove nicotinic receptors from the cell wall in a process called down-regulation, leaving fewer receptors available for binding.

另一理论，经元会主动减少细胞壁上烟碱，这一过程也称下调，从而减少可供结合数量。

COREY ALLARD: They didn't resemble known sensory  receptors instead they're most closely related to a family of receptors called  nicotinic acetylcholine receptors.

COREY ALLARD：它们不像已知感觉，相反，它们与称烟碱乙酰胆碱家族关系最密切。

Myasthenia gravis is a type II hypersensitivity disorder where the body produces antibodies that most commonly target nicotinic acetylcholine receptors on the surface of muscle cells.

重症肌无力是一种II型超敏反应，身产生抗，常见靶点肌肉细胞表面N胆碱抗。

First you've got your motor neurons that release the neurotransmitter acetylcholine at the neuromuscular junction, which then binds to nicotinic acetylcholine receptors on muscle cell membranes.

首先，你运动经元在经肌肉接头处释放经递质乙酰胆碱（ACh），然后与肌肉细胞膜上N胆碱相结合。

The upper motor neuron releases acetylcholine from its axon terminal knobs and these are received by nicotinic receptors on the alpha motor neuron.

上运动经元从轴突末端释放乙酰胆碱，作用于α运动经元上烟碱。

There are also medications that act on nicotinic receptors like buproprion and partial nicotine receptor agonists like varenicline which help reduce withdrawal symptoms and prevent relapse.

还有一些药物可以作用于烟碱，如盐酸安他非酮，以及烟碱部分激动剂，如瓦伦尼克林等，可以帮助减轻戒断综合征效应，防止复发。

The psychoactive effects of nicotine are related to the locations of nicotinic receptors in the brain and the exact neurotransmitters that are released when the receptors are stimulated.

尼古丁兴奋作用与烟碱在脑中位置以及激活所释放具经递质有关。

Once nicotine is absorbed into the bloodstream, it binds to a type of acetylcholine receptor, called a nicotinic acetylcholine receptor - also called a nicotinic receptor - which is found throughout the body and brain.

一旦尼古丁进入血液循环，它就会和一种乙酰胆碱结合，也称烟碱型乙酰胆碱或烟碱；这类广泛分布于身和大脑中。

VOICEOVER: Nicotinic acetylcholine  receptors are found throughout the nervous system of many different animals but  usually they detect neurotransmitters within the body and are involved with things  like controlling muscle contractions.

画外音：烟碱型乙酰胆碱存在于许多不同动物经系统中，但它们通常检测内经递质，并参与控制肌肉收缩等活动。

So nicotine, which is in e-cigarettes, for example, binds to a receptor called the nicotinic acetylcholine receptor, which plays a key role in the functioning of almost all organ systems in the human body.

例如，电子烟中尼古丁会与一种叫做烟碱型乙酰胆碱结合，这种在人几乎所有器官系统功能中起着关键作用。

In the central nervous system, nicotinic receptors are on pre-synaptic axon terminals of neurons, and when nicotine binds to them, it triggers the release of neurotransmitters like dopamine, acetylcholine, and glutamate, which is why it's considered an acetylcholine agonist.

在中枢经系统中，烟碱分布于突触前经元轴突末端，当尼古丁与结合后，会触发多巴胺、乙酰胆碱、谷氨酸盐等经递质释放，因此尼古丁被是一种乙酰胆碱兴奋剂。