Fluids may increase intra-erythrocyte free water and hinder the formation of sickling.
液可使红细胞内自水增加,从而阻止形。
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HbS carries oxygen perfectly well, but when it is deoxygenated, HbS changes its shape, which allows it to aggregate with other HbS proteins and form long polymers that distort the red blood cell into a crescent shape - a process called sickling.
HbS能够很好携氧,但在脱氧时,HbS会改状,从而使与它HbS蛋白聚集成长链多聚体,进而使红细胞扭曲成新月型,该程称为镰。