Thalassemia is a group of inherited blood disorders.

地是一组遗传性液疾病。

These are diseases like sickle cell anemia or beta thalassemia.

比如镰状细胞性β地。

And alpha thalassemia is caused by mutations in the alpha genes, most commonly a gene deletion.

而α地是由α基因变异引起，最常见原因是基因缺失。

Usually, patients with mild thalassemia don't need treatment, while patients with severe thalassemia are treated with blood transfusions.

通常情况下，轻度地无需治疗，而重度地患者需输治疗。

If a person has two defective alpha genes, the person has alpha thalassemia minor, which causes mild symptoms.

如果有2个α基因异常，则会出现轻度α地，会引起轻微症状。

With moderate alpha thalassemia, there may be golf-ball like RBCs, due to precipitated HbH molecules.

度α地患者，由于HbH分子沉积，可见高尔夫球样红细胞。

The initial symptoms of minor and moderate alpha thalassemia are due to anemia, which include pallor, shortness of breath, and easy fatigability.

轻度和度α地首发症状往往是，表现为苍白、气促、乏力。

All right, as a quick recap: alpha thalassemia is an autosomal recessive disorder caused by deletion of alpha globin genes on chromosome 16.

得！快速回顾一下：α地是一种常染色体隐性遗传病，由16号染色体上α珠蛋白基因缺陷引起。

To prevent complications from an existing blood or bleeding disorder, such as sickle cell disease, thalassemia, or anaemia caused by kidney disease, haemophilia, or von Willebrand disease.

预防现有液出性疾病并发症，如镰状细胞病、地由肾脏疾病、友病管性友病引起。