Doxifluridine was facilely synthesized from 5-fluorouracil in overall yield of 54.6% via trimethyl silylation, condensation, saponification, ketal formation, iodation, hydrogenolysis and hydrolysis.
以5-氟尿嘧啶为原料经硅醚
、和四乙酰核糖缩合、皂、酮缩醇形成、碘、
及水等反应合成了
氧氟尿苷。本法工艺简
、
件缓和、原料易得、成本低,总收率达54.6
